sedation and analgesia in the emergency department”. Am J Health-Syst Pharm. Vol69:1336-42. DOI 10.2146/ajhp110707
PROPOFOL
- Effect: Sedation and amnesia but does not elicit analgesic properties
- Initial Bolus Dosing (IV): 1 mg/kg
- Titration: 0.5 mg/kg every 3-5 min as needed
- Onset of Action IV: Fast (30-60 seconds)
- Duration of Action: Short (5-10 minutes)
- Adverse Effect: Respiratory depression and hypotension
Ketamine
- Effect: Unique procedural sedation agent, dissociative agent that creates a trance-like state and causes amnesia in patients, analgesic activity
- Initial Bolus Dosing (IV): 1-2 mg/kg
- Titration: 0.5 mg/kg every 5-10 min as needed
- Onset of Action IV: Fast (30-40 s)
- Duration of Action: Long (60 min)
- Adverse Effect: Dose-related increase in heart rate and blood pressure, increased inotropy causes increased myocardial oxygen demand
MIDAZOLAM
- Effect: Sedation, retograde amnesia
- Initial Bolus Dosing (IV): 0.1 mg/kg
- Titration: 0.1 mg/kg every 2 min as needed
- Onset of Action IV: Fast (2-5 min)
- Duration of Action: Short (30-80 min)
- Adverse Effect: respiratory depression and hypotension
FENTANYL
- Effect: Reduction and control of pain
- Initial Bolus Dosing (IV): 0.5-1.5 mcg/kg
- Titration: 0.5-1.5 mcg/kg every 1-3 min as needed
- Onset of Action IV: Rapid (1-2 min)
- Duration of Action: Short (30-60 min)
- Adverse Effect: Dose-dependent respiratory depression
Podcast: Play in new window | Download
Subscribe: Apple Podcasts | RSS | http://pharmsohard.com/