Vallentin MF, Granfeldt A, Meilandt C, et al. Effect of Intravenous or Intraosseous Calcium vs Saline on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial. JAMA. 2021 Nov 30. doi: 10.1001/jama.2021.20929. PMID: 34847226
- P: Adult patients with out of hospital cardiac arrest who received at least one dose of epinephrine.
- I: 5 mmol of Calcium Chloride given after the first and second dose of epinephrine
- C: Placebo
- O: Sustained ROSC = 19% in Calcium Group vs 27% in placebo group