Episode 62. The COCA Trial Review and Calcium in Cardiac Arrest

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Vallentin MF, Granfeldt A, Meilandt C, et al. Effect of Intravenous or Intraosseous Calcium vs Saline on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial. JAMA. 2021 Nov 30. doi: 10.1001/jama.2021.20929. PMID: 34847226

  • P: Adult patients with out of hospital cardiac arrest who received at least one dose of epinephrine. 
  • I: 5 mmol of Calcium Chloride given after the first and second dose of epinephrine 
  • C: Placebo
  • O:  Sustained ROSC = 19% in Calcium Group  vs 27% in placebo group

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Jimmy L. Pruitt III, PharmD, BCPS, BCCCP

The Pharm So Hard Podcast is a show focused primarily on emergency medicine and hospital pharmacy related topics. To empower healthcare providers with the knowledge and skills they need to provide evidence-based, safe care for critically ill patients.

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