Introduction
- Sodium bicarbonate was previously recommended for hyperkalemia treatment and was once considered a first-line agent for the transcellular shift.
- Studies evaluating the beneficial effects of sodium bicarbonate used an isotonic infusion commonly ~ 150 mEq/ 1000ml
- Hypertonic sodium bicarbonate or “amp of bicarb” has an osmolality of 2000 mOsm, about 7x higher than plasma.
- There’s controversy as to whether hypertonic sodium bicarbonate is beneficial for the acute treatment of hyperkalemia due to modifications in the mechanism of action.
Sodium Bicarbonate in Hyperkalemia Pharmacy Friday Pearl
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Refereneces
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Shingarev R, Allon M. A physiologic-based approach to the treatment of acute hyperkalemia. Am J Kidney Dis. 2010;56(3):578-584. doi:10.1053/j.ajkd.2010.03.014
- Sodium Bicarbonate. Micromedex [Electronic version].Greenwood Village, CO: Truven Health Analytics. Retrieved August 29, 2019, 2018, from http://www.micromedexsolutions.com/
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