If offered the COVID Vaccine, would you receive it?
— The Pharm So Hard Podcast (@pharmso_hard) December 13, 2020
Why did I make this episode?
- Family
- Friends
- Co-Workers
Why I wasn’t going to get the COVID Vaccine
- Skeptical of
- The speed at which the vaccine was produced
- Unfamiliarity with the mRNA Technology used
- Efficacy in patient-oriented outcomes
- Safety of the untested vaccine
Questions that I needed to answer
Who was influencing my thoughts on the vaccine?
Why does it seem like this vaccine is rushed?
How did COVID vaccines develop so quickly?
Has any other vaccine get developed in a short turnaround time?
What steps were “skipped” to make this vaccine become developed?
What are mRNA vaccines and how do they work?
Are these vaccines really effective or are they just another press release?
What outcomes were actually studied?
Are the vaccines safe for me to take?
PFIZER-BIONTECH COVID-19 VACCINE (BNT162, PF-07302048) VACCINES AND RELATED BIOLOGICAL PRODUCTS ADVISORY COMMITTEE BRIEFING DOCUMENT
VRBPAC-12.10.20-Meeting-Briefing-Document-SponsorPfizer Phase 3 Data




Oxford Data

References
https://www.fda.gov/media/144246/download
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Wu SC. Progress and Concept for COVID-19 Vaccine Development. Biotechnol J. 2020;15(6):e2000147. doi:10.1002/biot.202000147
Heaton PM. The Covid-19 Vaccine-Development Multiverse. N Engl J Med. 2020;383(20):1986-1988. doi:10.1056/NEJMe2025111
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https://www.cdc.gov/flu/pandemic-resources/2009-pandemic-timeline.html
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https://www.fda.gov/media/144246/download
https://www.nejm.org/doi/10.1056/NEJMoa2034577
Voysey M, Clemens SAC, Madhi SA, Weckx LY, Folegatti PM, Aley PK, Angus B, Baillie VL, Barnabas SL, Bhorat QE, Bibi S, Briner C, Cicconi P, Collins AM, Colin-Jones R, Cutland CL, Darton TC, Dheda K, Duncan CJA, Emary KRW, Ewer KJ, Fairlie L, Faust SN, Feng S, Ferreira DM, Finn A, Goodman AL, Green CM, Green CA, Heath PT, Hill C, Hill H, Hirsch I, Hodgson SHC, Izu A, Jackson S, Jenkin D, Joe CCD, Kerridge S, Koen A, Kwatra G, Lazarus R, Lawrie AM, Lelliott A, Libri V, Lillie PJ, Mallory R, Mendes AVA, Milan EP, Minassian AM, McGregor A, Morrison H, Mujadidi YF, Nana A, O’Reilly PJ, Padayachee SD, Pittella A, Plested E, Pollock KM, Ramasamy MN, Rhead S, Schwarzbold AV, Singh N, Smith A, Song R, Snape MD, Sprinz E, Sutherland RK, Tarrant R, Thomson EC, Török ME, Toshner M, Turner DPJ, Vekemans J, Villafana TL, Watson MEE, Williams CJ, Douglas AD, Hill AVS, Lambe T, Gilbert SC, Pollard AJ; Oxford COVID Vaccine Trial Group. Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. Lancet. 2020 Dec 8:S0140-6736(20)32661-1. doi: 10.1016/S0140-6736(20)32661-1. Epub ahead of print. PMID: 33306989; PMCID: PMC7723445.
Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockhart S, Perez JL, Pérez Marc G, Moreira ED, Zerbini C, Bailey R, Swanson KA, Roychoudhury S, Koury K, Li P, Kalina WV, Cooper D, Frenck RW Jr, Hammitt LL, Türeci Ö, Nell H, Schaefer A, Ünal S, Tresnan DB, Mather S, Dormitzer PR, Şahin U, Jansen KU, Gruber WC; C4591001 Clinical Trial Group. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. N Engl J Med. 2020 Dec 10. doi: 10.1056/NEJMoa2034577. Epub ahead of print. PMID: 33301246.
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